Clinical Publications

Orthopedic Surgery

  • Ascherl R et al. Therapy of Chronic Osteomyelitis with a compound of collagen and antibiotics- preliminary result. 1986
  • Lechner F et al. Collatamp G in the management of bone infection. Unpublished Report. 1984
  • Letsch R et al. Local antibiotic administration in osteomyelitis treatment – a comparative study with two different carrier substances. Aktuelle Traumatol. 1993; Nov: 23(7): 324-9.
  • Tørholm C et al. A multicenter comparison of the efficacy and safety of collagen with gentamicin sulfate with that of standard therapy in the treatment of osteomyelitis.
    Unpublished Report 1992
  • Von Hasselbach et al. Clinical aspects and pharmacokinetics of collagen-gentamicin as adjuvant therapy of osseous infections. Unfallchirurg, 1989; Sep 92(9):459-70
  • Feil J et al. The biologically absorbable collagen-gentamicin compound used as an intermedullary local antibiotic additive in cement-free total hip endoprosthesis.
    Unpublished Report. 1992
  • Hettfleisch J et al. Release of gentamicin from biomaterials implanted into the lumen of intramedullary load carriers – a pharmacokinetic study. Aktuelle Traumatol, 1993; Apr 23(2): 68-71.
  • Ascherl R et al. Local Infection treatment with collagen-gentamicin. Aktuelle Probl Chir Orthop, 1990; 34:85-93.
  • Attmanspacher W. et al. Medium-term results in the treatment of post-operative septic arthritis of the shoulder. Unfallchirurg Springler-Verlag, 2000; 103:1048-1056
  • Bremerich A et al. Local antibiotic therapy with Sulmycin Implant. Results of a pilot study. Zahnarztl Prax, 1988; Jul 8;39(7):256-7.
  • Eckstein T et al. First clinical experiences with a new collagen implant charged with gentamicin. Deutsch Zeitschrift fur Mund-, Kiefer- und Gesichts-Chir Year 3 1989/4.
  • Feil J et al. Bioresorbable collagen-gentamicin compound as local antibiotic therapy. Aktuelle Probl Chir Orthop, 1990; 34:94-103.
  • Ipsen T et al. Gentamicin-collagen sponge for local applications.Acta Orthop Scand,1991; Dec 62(6) 592-4.
  • Jerosch J. et al. Septic Arthritis: Arthroscopic Management With Local Antibotic Treatment, 1995; 61(2):126-34
  • Jerosch J. et al.Arthroscopic treatment of Septic Arthritis-Surgical Technique. Unfallchirurg, 1998; June:101(6):454-60
  • Lütten C et al. Exchange of operation with hip and knee joint endoprosthesis. Chir Praxis, 1989; 40: 287-291.
  • Spruit M et al. Revision of failed below knee amputations. Eur J Surg, 1994; May;160(5):267-70.
  • Steinig HL et al. Collagen-gentamicin in the treatment of osteomyelitis. In: Kollagen als Wirkstoffträger-Einsatzmöglichkeiten in der Chirurgie, Hrsg. Stuttgart; NY: Schattauer,1989; 70-74
  • Walz M et al. The use of collagen-gentamicin combination in open spongy bone plasty in chronic post-traumatic osteomyelitis. In: Aktuelle Probleme in Chirurgie und Orthopädie. 34: Infektion von Knochen und Gelenken, 2nd Ed. Verlag Hans Huber, Bern, 1990; 104-106.
  • Wernet E et al. Antibiotic-containing collagen sponge in therapy of osteitis. Unfallchirurg, 1992; May 95(5):259-64.
  • Wörschhauser S et al. Collagen-gentamicin in the treatment of osteomyelitis. In: Kollagen als Wirkstoffträger-Einsatzmöglichkeiten in der Chirurgie, Hrsg. Stuttgart; NY: Schattauer, 1989; 75-79

 

Abdominal and Colorectal

  • Arndt M et al. The application of resorbable antibiotic carriers in the area of sacral defects after abdominoperineal/rectal extirpation. Unpublished Report.
  • Wolvius R et al. Efficacy, release kinetics, and tolerance of a locally implanted antibiotic used in conjunction with primary wound closure for the prevention of infection after appendectomy. Unpublished Report 1992.
  • Gomez GGV et al. Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds. World J Surg, 1999; 23: 123-127.
  • Musella M et al. Collagen tampons as aminoglycoside carriers to reduce postoperative infection rate in prosthetic repair of groin hernias. Eur J Surg, 2001; Feb;167(2):130-2.
  • Nowaki P et al. Prospective, randomized trail examining the role of gentamycin containing collagen sponge in the reduction of postoperative morbidity in rectal cancer patients: early results and surprising outcome at 3 year follow up, Int J Colorectal DIS, 2005; 20:114-120.
  • Rahn H et al. A study of the efficacy and tolerability of local antibiotic prophylaxis using gentamicin-collagen implant (Sulmycin Implant) in patients undergoing abdominoperineal resection of the rectum.Unpublished Report, 1990. Unpublished Report.
  • Rutten H et al. Prevention of wound infection in elective colorectal surgery by local application of gentamicin-containing collagen sponge. Eur J Surg Suppl, 1997; (578):31-5.
  • Vogel P et al. Treatment of pilonidal sinus with excision and primary suture using a local, resorbable antibiotic carrier. Results of a randomized prospective study. Chirurg,1992; Sep;63(9):748-53.
  • Stemberger A et al. Local treatment of bone and soft tissue infections with collagen gentamicin sponge. Eur J Surg Suppl, 1997; 578:17-26.
  • Nielson et al. Contaminated fistula following J-pouch ileoanal reservoir (Case Report). Eur J Surg, 1991; Mar;157(3):219-20.
  • Schafer et al. Liver Resection And Diffuse Intra-Abdominal Bleeding. 1991
  • Rahn H et al. Abdominoperineal rectal extirpation. Chir Praxis, 1989/1990; 41: 637-643.
  • Kallehave et al. Topical antibiotics used in the treatment of complex wounds: A discussion of the use of collagen sponges impregnated with gentamicin in the treatment of six patients with complicated, infected, soft tissue wounds following gastrointestinal surgery. Journal of Wound Care, 1996; Vol.5 No.4.
  • Lampe F.et al. Necrosectomy with a Ultrasonic Dissector in the Treatment of Necrotizing Pancreatitis. Acta Chir Bleg, 2006; Vol 106, 177-180.
  • Kahle M. et al. Local infection prophylaxis with gentamicin-collagne sponge in Colostomy resection. Unpublished.
  • Szynglarewicz B. et al. Anastomosis wrapping with gentamicin-containing collagen sponge in rectal cancer patients following sphincter-preserving total mesorectal excision without defunctioning stoma. Case Rep Clin Pract Rev, 2006; 7:267-271.
  • Meyer L. et al. Perineal wound closure after abdominal-perinal excision of the rectum. Tech Coloproctol, 2004; 8:s230-s234.

 

Cardiothoracic Surgery

  • Leyh RG et al. Adjuvant treatment of deep sternal wound infections with collagenous gentamicin. Ann Thorac Surg, 1999; Nov 68(5):1648-51.
  • Eklund A.M. et al. Prophylaxis of sternal wound infection with gentamicin-collagen implant: randomized controlled study in cariac surgery. Journal of Hospital Infection,2005; 59, 108-112.
  • Friberg O et al. Antibiotic concentrations in serum and wound fluid after local gentamicin or intravenous dicloxacillin prophylaxis in cardiac surgery. Scand J Infect Dis, 2003; 35(4):251-4
  • Friberg O et al. Local gentamicin reduces the sternal wound infections after cardiac surgery: a randomized controlled trial. Ann Thorac Surg, 2005; Jan; 79(1):153-61
  • Friberg O et al. Cost effectiveness of local collagen gentamicin as prophylaxis for sternal wound infections in different risk groups. Scandinavian Cardiovascular Journal, 2005
  • Friberg O et al. Influence of more than six sternal fixation wires on the incidence of deep sternal would infection. Thirac Cardiov Surg, 2006; 54:468-473
  • Friberg 0 et al. Incidence, Microbiological findings , and clinical presentation of sternal would infections after cardiac surgery with and without gentamicin prophylaxis. FarJ Clin Microbiol Dis, 2007; 26: 91-97
  • Cyba-Altunbay S et al. Perioperative prophylaxis of infection in vascular chest surgery in infected tissue. Unpublished.
  • Kusch E. Use of Sulmycin® Implant and Fibrin Glue to close a bronchial stump after pneumonectomy (1995)

 

Vascular Surgery

  • Hansen B et al. Gentacoll for treatment of infected vascular prosthesis. Unpublished Report.
  • Horch R et al. Prevention of infection in Teflon prostheses for dialysis access: experiences with a resorbable combined collagen-antibiotic system. Vasa, 1989; 18(1):30-4.
  • Jørgensen et al. Clinical and pharmacokinetic evaluation of gentamicin-containing collagen in groin wound infections after vascular reconstruction. Eur J Vasc Surg, 1991 Feb; 5(1):87-91
  • Belz R et al. Use of gentamicin-collagen fleece in vascular surgery. Angio, 1989; 11(4):147-152.
  • Holdworth J. Treatment of infective and potentially infective complications of vascular bypass grafting using gentamicin with collagen sponge. Ann R Coll Surg Engl, 1999 May;81(3):166-70.

 

Neurosurgery

  • Rohde .V.M.D . Spondylodiscitis after Lumbar Discectomy: Incidence and a Proposal for Prophylaxis. Spine, 1998; Vol 23.No.5 pp 615-620.
  • Kolodziejcyk D. Epidural "Sulmycin Implant" –coverage of local infection prophylaxis in surgical treatment of penetrating head injuries. Akt Traumatol,1992; 22. 272-275
  • Zink PM et al. Prophylaxis of postoperative lumbar spondylodiscitis. Neurosurg Rev, 1989; 12(4) 297-303.

 

Gynecological

  • Szpaczek J. et al. Applying a local antibiotic (Garamycin Implant Schwamm specimen) in surgical treatment of purulent complications in gynecology. Ces. Gynek, 1998; No. 63 book 3, p 233-235.

 

Podiatry

  • Arlt B et al. Diabetic Foot. Langenbecks Arch Chir, 1997; Suppl II
  • Faludi S. et al. Experience Acquired by Applying Gentamicin-Sponge. Acta Chirurgica Hungarcia, 1997; 36(1-4) pp 81-82
  • Formiga S. et al. Treatment of Leg Ulcers with Collagen and Gentamicin implant (Preliminary Study). MEDIMOND INC, 2000

 

Mixed Tissue

  • Stemberger A et al. A biological drug-carrier in soft tissue infections. Prog Angio, 1988; 275-277.
  • Beyer P et al. Collagen with gentamicin implant in soft tissue infections. In: Kollagen als Wirkstoffträger-Einsatzmöglichkeiten in der Chirurgie, Hrsg. Stuttgart; NY. Schattauer, 1989; 79-80.
  • Kiffner E et al. Local therapy of infection with absorbable antibiotic carriers. Klinik Artz,1989; 1, 3-6.
  • Kwasny O et al. The use of gentamicin collagen floss in the treatment of infections in trauma surgery. Orthopedics, 1994; May;17(5):421-5.

 

Abscess

  • Castor B. Local Antibiotic Therapy via a Fistula : Treatment of a Postoperative Abscess with Collagen and Gentamicin. Scand J Infect, 1999; 31:216
  • Schafer et al, Is the Primary Suture Indicated in Infected Wounds in Pediatric Surgery, Langenbecks Arch Chir Supp II. Kongrebeacht, 1997; 1